Blar i forfatter "Gombos, Imre"

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    • Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells 

      Crul, Tim; Csoboz, Balint; Gombos, Imre; Marton, Annamaria; Peter, Maria; Balogh, Gabor; Vizler, Csaba; Szente, Lajos; Vigh, Laszlo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-12)
      The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and ...

    • The Small Heat Shock Protein, HSPB1, Interacts with and Modulates the Physical Structure of Membranes 

      Csoboz, Balint; Gombos, Imre; Kóta, Zoltán; Dukic, Barbara; Klement, Éva; Varga-Zsíros, Vanda; Lipinszki, Zoltán; Páli, Tibor; Vígh, László; Török, Zsolt (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-30)
      Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and modulate the physical state of membranes across species. Through these interactions, sHSPs contribute to the maintenance of membrane integrity. HSPB1 is a major sHSP in mammals, but its lipid interaction profile has so far been unexplored. In this study, we characterized the interaction between HSPB1 and phospholipids. ...